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VA Center For Medication Safety (VA MedSAFE)

Bulletins And News Alerts

Alerts are based on the clinical evidence available at the time of publication. Recommendations are intended to assist practitioners in providing consistent, safe, high quality, and cost effective drug therapy. They are not intended to interfere with clinical judgment.  When using dated material, the clinician should consider new clinical information, as available and applicable.

Safety Issue Date of Release Safety Information
Synthetic_Marijuana_Potential_Risk_for_Bleeding_NATIONAL_PBM BULLETIN_FINAL_040518_with_disclaimer   National PBM Bulletin
Sofosbuvir/Velpatasvir (Epclusa) and Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi) Look-Alike/Sound-Alike Potential 01/26/2018 National PBM Bulletin
Edaravone (Radicava™) and Potential for Leaking at Valve Site 01/10/2018 National PBM Bulletin
Enoxaparin Sodium Injection: Recall Due to Incorrect Strength Syringe in Blister 12/28/2017 National PBM Patient Level Recall Communication
Calcimimetic Therapy in Patients on Dialysis: Risk of Duplicate Therapy and Safety Considerations 12/26/2017 National PBM Bulletin
Diphenoxylate Hydrochloride and Atropine Sulfate Tablets : Recall Due to Possible Sub Potent and Super Potent Tablets 12/05/2017 National PBM Patient Level Recall Communication
Febuxostat (Uloric): FDA Evaluates Risk of Cardiovascular Death 11/21/2017 National PBM Bulletin
Afluria Pre-filled Syringe Label Creates the Potential for Confusion 11/15/2017 National PBM Bulletin
Magic3® HydroSil Gripper and Personal Intermittent Catheters: Recall for Sterile Barrier Breach 10/23/2017 National PBM Patient Level Recall Communication
Addendum - Procrit® (epoetin alfa) 1 mL Single-Dose, Preservative-Free Solution: Recall Due to Presence of  Glass Particles 09/25/2017 National PBM Patient Level Recall Communication
Medtronic Recall of MiniMed Infusion Sets Due to Potential Over-Delivery of Insulin 09/18/2017 National PBM Patient Level Recall Communication
Procrit® (epoetin alfa) 1 mL Single-Dose, Preservative-Free Solution: Recall Due to Presence of  Glass Particles 09/01/2017 National PBM Patient Level Recall Communication
Lorazepam Oral Concentrate, USP 2mg/mL Recall Due to Misprinted Dosing Droppers Supplied with the Product 08/23/2017 National PBM Patient Level Recall Communication
Magnesium Citrate Recall Due to Product Contamination 08/17/2017 National PBM Patient Level Recall Communication
Leader Brand, Major Pharmaceuticals, and Rugby Laboratories Recall of ALL Liquid Products Manufactured by PharmaTech Due to B. cepacia Contamination Risk 08/15/2017 National PBM Patient Level Recall Communication
Becton Dickinson - Insulin Syringes:Recall Due to Incorrect Product Labeling 06/15/2017 National PBM Patient Level Recall Communication
Apixaban (Eliquis®) Recall Due to Incorrect Strength in Bottle 06/08/2017 National PBM Patient Level Recall Communication
EpiPen and and EpiPen Jr Auto-Injector: Recall - Failure to Activate Device 04/04/2017 National PBM Patient Level Recall Communication
Direct-Acting Antiviral Safety Issues 03/14/2017 National PBM Bulletin
ADDENDUM: Mirtazapine Tablets, USP 45mg – Ongoing Recall Due to Commingled Tablets 03/08/2017 National PBM Patient Level Recall Communication
Mirtazapine Tablets, USP 45mg – Recall Due to Potential of Commingled Tablets 03/07/2017 National PBM Patient Level Recall Communication
Alprostadil for Injection (Edex®) – Recall Due to Potential Lack of Sterility Assurance 03/06/2017 National PBM Patient Level Recall Communication
Chlorhexidine Gluconate Safety 02/07/2017 National PBM Bulletin
Liquid Products Recall (PharmaTech) Due to Potential Risk of Product Contamination 10/12/2016 National PBM Patient Level Recall Communication
GlucaGen® HypoKit® (Novo Nordisk Inc.) Recall Due to Needle Detachment from Syringe 09/14/2016 National PBM Patient Level Recall Communication
Eye Wash/Eye Irrigating Soutions Recall Due to Microbial Contamination 09/09/2016 National PBM Patient Level Recall Communication
Topical Skin Products Recall Due to Microbial Contamination 08/29/2016 National PBM Patient Level Recall Communication
Amikacin Recall Due to Particulate Matter in Vials 08/08/2016 National PBM Patient Level Recall Communication
Bactroban (Mupirocin) Recall Expansion 08/04/2016 National PBM Patient Level Recall Communication
Lithium Safety 07/25/2016 National PBM Bulletin
Various Diabetic Test Strips Recall (specific sites only) 07/12/2016 National PBM Patient Level Recall Communication
Contaminated Oral Liquid Docusate 06/29/2016 National PBM Patient Level Recall Communication
Fluoroquinolone Safety 06/03/2016 National PBM Bulletin
Ketoconazole Safety 05/31/2016 National PBM Bulletin
Canagliflozin and Risk of Amputations 05/31/2016 National PBM Bulletin
Antipsychotic Agents and Safety Issues 05/13/2016 National PBM Bulletin
Metformin Revised Warnings 04/18/2016 National PBM Bulletin
Thyrogen® (thyrotropin alfa for injection) Recall Due to Glass Particulates 04/01/2016 National PBM Patient Level Recall Communication 
Idelalisib Safety 03/29/2016 National PBM Bulletin
Amikacin Recall Due to Glass Particulates 03/15/2016 National PBM Patient Level Recall Communication
Noxafil (Posaconazole):  Dosing Errors When Switching Between Different Oral Formulations 01/13/2016 National PBM Bulletin
Bactroban (Mupirocin) Recall:  ADDENDUM 12/17/2015 National PBM Patient Level Recall Communication
OmniPod Insulin Management System Recall:  ADDENDUM 12/14/2015 National PBM Patient Level Recall Communication
Auvi-Q (epinephrine injection, USP) Recall - Potential Inaccurate Dosage Delivery 10/30/2015 National PBM Patient Level Recall Communication
BD Syringes and Loss of Drug Potency:  FDA Expands Warning - UPDATE 09/23/2015 National PBM Bulletin
OmniPod Insulin Management System Recall 09/15/2015 National PBM Patient Level Recall Communication
Allergan Ophthalmic Product Recall Due to Particulate Matter:  ADDENDUM 09/04/2015 National PBM Patient Level Recall Communication
Allergan Ophthalmic Product Recall Due to Particulate Matter 09/02/2015 National PBM Patient Level Recall Communication
BD Syringes and Loss of Drug Potency 08/31/2015 National PBM Bulletin
Adverse Cardiovascular Thrombotic Events with NSAIDs:  FDA Strengthens Warning 08/04/2015 National PBM Bulletin
Ketorolac Recall Due to Particles in Glass Vial:  ADDENDUM 07/02/2015 National PBM Patient Level Recall Communication
Nexium Recall Due to Bottle Containing Seroquel Instead 06/24/2015 National PBM Patient Level Recall Communication
SGLT2 Inhibitors and Potential Risk for Acidosis 05/22/2015 National PBM Bulletin
Ketorolac Recall Due to Particles in Glass Vial 05/04/2015 National PBM Patient Level Recall Communication
Ferumoxytol and Risk of Serious Allergic Reactions 04/28/2015 National PBM Bulletin
Amiodarone Use with Ledipasvir/Sofosbuvir (Harvoni) or Sofosbuvir (Sovaldi) Combined with Another Direct-Acting Antiviral and Bradycardia 03/31/2015 National PBM Bulletin
UPDATE:  Testosterone Products and Cardiovascular Safety 03/26/2015 National PBM Bulletin
DAPT Trial and Risk of Non-Cardiovascular Death 12/17/2014 National PBM Bulletin
Dimethyl Fumarate (Tecfidera) and PML Resulting in Death 11/07/2014 National PBM Bulletin
Creon Recall Due to Presence of Capsule of Incorrect Strength in Bottle 10/03/2014 National PBM Communication
Digoxin in Patients with Atrial Fibrillation: Potential Harms 09/30/2014 National PBM Bulletin
UPDATE:  Niacin Study Results and Implications 08/29/2014 National PBM Bulletin
Acetaminophen Safety 06/10/2014 National PBM Bulletin
Eszopiclone (Lunesta): Lowered Dose Recommendations Due to Next-Day Impairment 05/28/2014 National PBM Bulletin 
Adverse Neurologic Events and Epidural Corticosteroid Injections for Pain 05/01/2014 National PBM Bulletin 
Alli (orlistat) Recall Due to Product Tampering 04/04/2014 National PBM Communication 
Effexor and Venlafaxine Recall for Possible Presence of Tikosyn Capsules 03/10/2014 National PBM Communication 
Saxagliptin and Cardiovascular Safety 02/18/2014 National PBM Bulletin 
Testosterone Products and Cardiovascular Safety 02/07/2014 National PBM Bulletin 
ADDENDUM:  Additional Lots Identified for Abbott Freestyle Glucose Test Strips Recall 12/04/2013 National PBM Communication 
Abbott FreeStyle Glucose Test Strips Recall 11/29/2013 National PBM Communication 
Regadenoson (Lexiscan) and Adenosine (Adenoscan): Risk of Heart Attack and Death 11/29/2013 National PBM Bulletin 
Imitrex STATdose System and Sumatriptan Succinate Injection Refill 6mg Recall 11/22/2013 National PBM Communication 
LMWHs and Increased Risk of Spinal Column Bleeding and Paralysis 11/15/2013 National PBM Bulletin 
Low Molecular Weight Heparins (LMWHs) and Increased Risk of Spinal Column Bleeding and Paralysis 11/15/2013 National PBM Bulletin 
Tigecycline (Tygacil) and Increased Risk of Death 10/01/2013 National PBM Bulletin 
Nova Max Glucose Test Strips Recall Due To Falsely Elevated Blood Glucose Results 08/14/2013 National PBM Communication 
Valproate Use During Pregnancy and Lower IQ in Children Exposed 08/06/2013 National PBM Bulletin 
Medtronic Recall of Reservoirs Used with Paradigm Insulin Pumps Due to Leaks 07/23/2013 National PBM Communication 
Hydoxyethyl Starch Solutions and Mortality and Acute Kidney Injury 07/19/2013 National PBM Bulletin 
Aspirin Lot Recalled for Containing Acetaminophen Instead 07/01/2013 National PBM Communication 
Prevnar 13 and Pneumovax 23: Medication Errors and Appropriate Use 04/10/2013 National PBM Bulletin 
Sodium Phosphate Enema and Fatal Outcome 03/26/2013 National PBM Bulletin 
Peginesatide Injection Recall and Anaphylaxis

03/04/2013

National PBM Communication 
Dual Renin-Angiotensin Aldosterone System Blockade and Impaired Renal Function and Hyperkalemia 02/12/2013 National PBM Bulletin
Rugby Ferrous Sulfate Recall Due to Bottle Improperly Containing Meclizine HCL 25 mg Tablets 01/13/2013 National PBM Communication
Zolpidem and Proposed Lower Doses Due to Impaired Mental Alertness 01/16/2013 National PBM Communication 
Ondansetron 32mg Single IV Dose Market Withdrawal Due to Cardiac Risks 12/05/2012 National PBM Bulletin 
Dabigatran (Pradaxa®) and Packaging Error - Recall Due to Possible Compromise in Product Quality 11/09/2012 National PBM Communication 
Ameridose Recall of All Unexpired Product Line 11/01/2012 National PBM Communication 
ADDENDUM: Fungal Meningitis Outbreak and Additional Patient Notification 10/18/2012 National PBM Communication 
Compounded Epidural Steroid Injections and Meningitis Outbreak 10/05/2012 National PBM Communication 
Citalopram (Celexa®) and Dose-Dependent QT Interval Prolongation: UPDATED RECOMMENDATIONS 04/17/2012 National PBM Bulletin 
Lo/Ovral-28 and Norgestrel/Ethinyl Estradiol Tablets - Recall for Inexact Tablet Counts or Out of Sequence Tablets 02/03/2012 National PBM Communication 
Aliskiren: Adverse Drug Events When Concomitantly Used with ACE Inhibitors or ARBs in Patients with Type II DM 01/13/2012 National PBM Bulletin 
Dronedarone and Cardiovascular Events in Permanent Atrial Fibrillation 01/10/2012 National PBM Communication 
Lexiscan® (Regadenoson) Update: New Safety Labeling Changes Approved By FDA 11/15/2011 National PBM Communication 
Target Dose of Angiotensin II Receptor Antagonists in Patients with Heart Failure 10/31/2011 National PBM Communication 
Citalopram Hydrobromide (Celexa®) and Dose-Dependent QT Interval Prolongation: UPDATE 09/29/2011 National PBM Bulletin 
Oral Contraceptives and Packaging Error Recall 09/21/2011 National PBM Communication 
Erythropoiesis-Stimulating Agents (ESAs) in Chronic Kidney Disease (CKD) and New Dosing Recommendations 08/09/2011 National PBM Communication 
Dronedarone (Multaq®) and Risk of Death and Serious CV Events in Patients with Permanent AF 07/28/2011 National PBM Communication 
Colistimethate for Injection and Dosing Confusion 07/08/2011 National PBM Bulletin 
Recall of Butalbital, APAP, and Caffeine Tablets and Hydrocodone Bitartrate and APAP Tablets – Mislabeling 06/30/2011 National PBM Communication 
Churchill Medical Skin-Prep Wipes Recall Due to Bacterial Contamination 06/17/2011 National PBM Communication 
SimplyThick Thickening Gel Products Recall and Possible Presence of Bacteria 06/10/2011 National PBM Communication 
Simvastatin: Updated Restrictions, Contraindications and Dose Limitations 06/09/2011 National PBM Bulletin 
ADDENDUM: Warfarin and High PotencyEXPANDED Recall 06/02/2011 National PBM Communication 
ADDENDUM: Smith & Nephew Various Adhesive Remover Wipes and Potential ContaminationRECALL 05/31/2011 National PBM Communication 
Nitroglycerin Tablets and Packaging Error Recall 05/25/2011 National PBM Communication 
Smith & Nephew Various Adhesive Remover Wipes and Potential Contamination RECALL 05/20/2011 National PBM Communication 
Marcaine Incorrect Labeling and Potential Look-Alike Confusion 05/13/2011 National PBM Bulletin 
Warfarin and High Potency Recall 05/12/2011 National PBM Communication 
Citalopram and Finasteride Recall Due to Mislabeling 03/31/2011 National PBM Communication 
Povidine® Iodine Prep Pads and Potential Microbial Contamination Recall 03/29/2011 National PBM Communication 
Dexamethasone Sodium Phosphate Inj USP 4mg/ml and Particulate Formation Recall 03/23/2011 National PBM Communication 
PPIs: Long-Term Use and Risk of Hypomagnesemia 03/11/2011 National PBM Communication 
Dicyclomine and Doxycycline LASA Confusion 03/10/2011 National PBM Bulletin 
Maternal and Newborn Risks with Certain Medications Used During Pregnancy 03/09/2011 National PBM Communication 
Albuterol Sulfate Inhalation Solution Recall- Packaging Error 02/11/2011 National PBM Communication 
Dronedaraone and Liver Injury  01/27/2011 National PBM Communication 
Triad Group Recall – Sterile Lubricating Jelly and Alcohol Swabs  01/20/2011 National PBM Communication 
Abbott Glucose Test Strips Recall  12/28/2010 National PBM Communication 
Propoxyphene and Cardiac Toxicity  11/19/2010 National PBM Bulletin 
Dronedaraone and Adverse Events Reported in ISMP  11/15/2010 National PBM Communication 
Epoetin Alfa (Epogen and Procrit) Voluntary Recall  09/28/2010 National PBM Communication 
Regadenoson (Lexiscan) and Updated Labeling  09/22/2010 National PBM Communication
New Considerations for the Safe and Effective Use of Colchicine  07/15/2010 National PBM Bulletin 
Heparin and Potency Variation: UPDATE  04/07/2010 National PBM Communication
Clopidogrel and Boxed Warning Regarding Poor Metabolizers  03/25/2010 National PBM Bulletin
LABA Safety in Asthmatic Patients  03/09/2010 National PBM Communication
Clopidogrel and Omeprazole Drug Interaction  02/12/2010 National PBM Bulletin
Natalizumab and the Risk for Developing PML and IRIS  02/09/2010 National PBM Bulletin
Sirolimus Monitoring  01/22/2010 National PBM Bulletin
Safety of High Dose Statin-Fibrate Combinations  11/10/2009  National PBM Bulletin 
Influenza Vaccine Adverse Event Reporting  10/19/2009  National PBM Bulletin 
Heparin and Potency Variation  10/02/2009  National PBM Communication 
Sitagliptin and Acute Pancreatitis  09/29/2009  National PBM Communication 
Vitamin D: High Dose Use and Safety  09/15/2009  National PBM Bulletin 
Fentanyl Transdermal System Recall Due to Leaking Contents  08/20/2009  National PBM Communication 
Dextroamphetamine/Amphetamine 20mg Tablet recall Due to Weight Variability  08/20/2009  National PBM Communication 
Risk of Severe Hypoglycemia with Glyburide Use in Elderly Patients with Renal Insufficiency  07/29/2009  National PBM Bulletin 
Propofol and Urgent Drug Recall by Teva Due to Contaminated Lots  07/14/2009  National PBM Communication 
Medtronic and Quick-Set Infusion Sets Recall  07/13/2009  National PBM Communication 
Varenicline and Bupropion and Neuropsychiatric Adverse Events  07/02/2009  National PBM Communication 
Oxybutynin and Oxycodone and LASA Confusion  07/02/2009  National PBM Bulletin 
Citalopram and Tablet Size Variance Recall  06/30/2009  National PBM Communication 
Tacrine and Tacrolimus LASA Confusion  06/25/2009  National PBM Bulletin 
Leukotriene Inhibitors and Neuropsychiatric Adverse Events  06/15/2009  National PBM Communication 
TNF-a Blockers, including Simponi [golimumab], and Risk of Fungal Infections  05/27/2009  FDA MedWatch Safety Alert 
Macrodantin and Macrobid LASA Confusion  05/06/2009  National PBM Bulletin 
Regadenoson (Lexiscan) and Updated Labelling  05/05/2009  National PBM Communication 
Clevidipine and Propofol Potential Look-Alike Confusion  04/30/2009  National PBM Communication 
Ceftriaxone (Rocephin) and Calcium Interaction  04/29/2009  National PBM Communication 
Digoxin and Tablet Size Variability Recall  04/02/2009  National PBM Communication 
Infed (Iron Dextran) and Precipitate Formation Recall  04/02/2009  National PBM Communication 
Propafenone HCL 225mg (Watson) and Variability in Active Ingredient Recall  03/30/2009  FDA Recall - Firm Press Release 
Transdermal Patches Containing Metal and Risk of Burns  03/05/2009  FDA Public Health Advisory 
Rapitiva (Efalizumab) and PML  03/03/2009  National PBM Communication 
Metoclopramide and Risk of Tardive Dyskinesia  02/26/2009  FDA News 
Zonisamide (marketed as Zonegran, and generics) and Possible Metabolic Acidosis  02/23/2009  FDA Information for Healthcare Professionals 
Clopidogrel and Alteration of Effectiveness Due to CYP219 Inhibition  01/29/2009  National PBM Communication 
Duragesic Patch (50mcg/hr) and Cut in Drug Reservoir Recall  12/31/2008  Johnson and Johnson News 
Visicol and Osmoprep and Acute Phosphate Nephropathy  12/19/2008  National PBM Communication 
Methadone QTc Prolongation and Torsades de Pointes  12/17/2008  National PBM Communication 
LIFESCAN OneTouch SureStep Test Strips and Inaccurate Readings – RECALL  12/04/2008  National PBM Communication 
Phenytoin and Fosphenytoin and Serious Skin Reactions  12/03/2008  National PBM Communication 
Erlotinib (Tarceva) and Hepatic Impairment  12/01/2008  National PBM Communication 
ETHEX Recall  11/14/2008  National PBM Communication 
ETHEX Propafenone Recall Patient Letter  11/12/2008  National PBM Communication 
ETHEX Recall  11/12/2008  National PBM Communication 
Concentrated Opioid Solutions and Concentration Confusion  11/12/2008  National PBM Bulletin 
Natalizumab and PML  10/31/2008  National PBM Communication 
Varenicline and Increase in Reports of Serious Adverse Events  10/28/2008  National PBM Communication 
Iron Dextran and the Adverse Drug Events Associated with the High Molecular Weight Formulation   10/21/2008  National PBM Bulletin 
Calcium and Vitamin D and Change in Formulation  10/06/2008  National PBM Bulletin 
Look-Alike Error with Acetic Acid and Sterile Water Irrigation  10/02/2008  National PBM Bulletin 
Rituximab and PML  9/19/2008  National PBM Communication 
TNF Inhibitors and the Risk for Invasive Fungal Infections  09/05/2008  National PBM Bulletin 
EPOGEN® and Amgen Announcing Nationwide Voluntary Recall  08/28/2008  Patient Letter 
EPOGEN® and Amgen Announcing Nationwide Voluntary Recall  08/28/2008  National PBM Communication 
Natalizumab and PML  08/27/2008  National PBM Communication 
Ezetimibe/Simvastatin (Vytorin®), Simvastatin, and Ezetimibe (Zetia®) and Risk for Cancer  08/26/2008  National PBM Communication 
Naltrexone Injection Site Reactions  08/20/2008  National PBM Alert 
Exenatide (Byetta) and Hemorrhagic and Necrotizing Pancreatitis  08/19/2008  National PBM Response 
Simvastatin and Amiodarone Drug-Drug Interaction  8/18/2008  National PBM Response 
Mitoxantrone and Recommendations for Increased Monitoring  8/18/2008  National PBM Response 
PROCRIT® (EPOETIN ALFA) LOT NUMBER P114942A and Nationwide Voluntary Recall of Ortho Biotech  8/8/2008  National PBM Response 
PROCRIT® (EPOETIN ALFA) LOT NUMBER P114942A and Nationwide Voluntary Recall of Ortho Biotech – Patient Letter  8/8/2008  Patient Letter 
Erythropoiesis Stimulating Agents (ESAs ): FDA Labeling Changes for Cancer Patients Receiving Myelosuppressive Chemotherapy  8/8/2008  National PBM Update Alert 
Topical Thrombin and Safety Issues if Used Intravascularly  8/7/2008  National PBM Alert 
Bevacizumab Plus Sunitinib and Potential for Developing Microangiopathic Hemolytic Anemia  7/31/2008  National PBM Alert 
Micro-Bubble Contrast Agents (Definity® [Perflutren Lipid Microsphere] Injectable Suspension and Optison® [Perflutren Protein-Type A Microspheres] for Injection): Risk of Cardiopulmonary Reactions and Changes to Package Labeling  7/18/2008  National PBM Alert 
Nationwide Recall of Sodium Polystyrene Sulfonate Suspension, USP (15g/60ml) (NDC 0054-0165-51; Lot 856396A Expiration April 2010, and Lot 856693A ExpirationMay 2010)  7/17/2008  National PBM Alert 
Nationwide Recall of Sodium Polystyrene Sulfonate Suspension, USP (15g/60ml) (NDC 0054-0165-51; Lot 856396A Expiration April 2010, and Lot 856693A ExpirationMay 2010)  7/17/2008  Patient Letter 
Fluoroquinolone Use and the Potential for Tendinitis and Tendon Rupture  7/10/2008  National PBM Bulletin 
CellCept® (mycophenolate mofetil) and Cases of Progressive Multifocal Leukoencephalopathy (PML)  7/1/2008  National PBM Bulletin 
Varenicline (marketed as Chantix) and Recent Safety Issues  6/20/2008  Patient Letter (VA Secretary) 
Antipsychotic Use and Increase Risk of Death in Patients with Dementia-Related Psychosis  6/16/2008  FDA Information for Healthcare Professionals 
Becaplermin (Regranex) Safety Information and Labeling Changes   6/11/2008  National PBM Bulletin 
Tumor Necrosis Factor (TNF) Antagonists and the Development of Lymphomas and Other Cancers in Children and Young Adults (< 18 years)  6/4/2008  FDA Early Communication 
Varenicline (marketed as Chantix) and Recent Safety Issues  5/30/2008  National PBM Bulletin Addendum 
Varenicline (marketed as Chantix) and Recent Safety Issues  5/30/2008  VA Patient Letter 
Aprotinin (Trasylol®) and Increased Risk of Death and Other Serious Adverse Events – Temporary Suspension in Marketing  5/16/2008  National PBM Bulletin 
Use of Abacavir or Didanosine and Higher Risk of Heart Attack  4/4/2008  National HIV/AIDS Program Commentary 
Heparin Manufacturer Recalls  4/2/2008  B. Braun Internal Distribution Letter 
Heparin Manufacturer Recalls  3/28/2008  FDA Firm Press Release – Covidien Voluntary recall of Heparin Pre-Filled Syringes 
Use of Abacavir or Didanosine and Higher Risk of Heart Attack  3/27/2008  FDA Early Communication 
Heparin Manufacturer Recalls  3/27/2008  Advanced Medical Internal Distribution Letter 
Heparin Manufacturer Recalls  3/21/2008  Advanced Medical Manufacturer Letter 
Heparin Manufacturer Recalls  3/25/2008  Advanced Medical Important Notice 
Heparin Manufacturer Recalls  3/21/2008  FDA Firm Press Release for B.Braun Medical, Inc. 
Heparin Manufacturer Recalls  3/20/2008  B.Braun Urgent Drug Recall 
Update: Baxter Heparin Sodium Recall – Alternatives to Heparin Sodium  3/19/2008  Update 
Etanercept and Tuberculosis and Infections   3/14/2008  Dear Healthcare Professional Letter (Amgen) 
EPOGEN®/PROCRIT® and Aranesp® and Additional Trials Showing Increased Mortality and/or Tumor Progression  3/7/2008  Dear Healthcare Professional Letter (Amgen) 
Update: Baxter Heparin Sodium Recall  3/3/2008  Update B. Braun – April 2008 
Calcium Supplements and Cardiovascular Disease in Older Women  3/1/2008  Review of a recent BMJ Article 
Baxter - Allergic Reactions to Heparin Sodium  2/19/2008  National PBM Bulletin 
Antiepileptic Drugs and Suicidality  2/11/2008  National PBM Bulletin 
Temsirolimus (Torisel®) Final Dose Concentration  2/7/2008  National PBM Bulletin Addendum 
Temsirolimus (Torisel®) Final Dose Concentration  1/22/2008  National PBM Bulletin 
Haloperidol and Cyanocobalamin 1ML Vials – Look-Alike Safety Alert  12/20/2007  National PBM Bulletin 
IV Haloperidol and Torsades de Pointe  11/28/2007  Updated Labeling 
Myfortic® (mycophenolic acid) and Increased Risks of Pregnancy Loss and Congenital Malformations / Change from Pregnancy Category C to Pregnancy Category D  11/27/2007  Dear Healthcare Professional Letter (Novartis) 
Varenicline (marketed as Chantix) and Suicidal Thoughts and Aggressive or Erratic Behavior  11/20/2007  FDA Early Communication 
Varenicline (marketed as Chantix) and Suicidal Thoughts and Aggressive or Erratic Behavior  11/20/2007  FDA Patient Information Sheet 
Varenicline (marketed as Chantix) and Suicidal Thoughts and Aggressive or Erratic Behavior  11/20/2007  PBM Update: Varenicline Safety 
Rosiglitazone and Increased Risk of Myocardial Ischemia  11/19/2007  FDA Information for Healthcare Professionals 
Erythropoiesis Stimulating Agents Safety Alert  11/15/2007  National PBM Bulletin Addendum 
Sildenafil (marketed as Viagra and Revatio) Vardenafil (marketed as Levitra) Tadalafil (marketed as Cialis) and Hearing Loss  11/14/2007  FDA Information for Healthcare Professionals 
Cefipime (marketed as Maxipime) and Increased Mortality  11/14/2007  FDA Early Communication 
Aprotinin (Trasylol®) and Increased Risk of Death and Other Serious Adverse Events – Temporary Suspension in Marketing  11/6/2007  National PBM Bulletin 
Codeine Use in Breast-Feeding Women  10/9/2007  National PBM Bulletin 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products UPDATE  9/28/2007  National PBM Bulletin 
IV Haloperidol and Torsades de Pointe  9/17/2007  FDA MedWatch Summary 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products UPDATE  9/11/2007  FDA Alert 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products UPDATE  9/11/2007  Information for Healthcare Professionals (FDA) 
Viracept (nelfinavir mesylate) and presence of ethyl methanesulfonate (EMS), a process-related impurity  9/10/2007  FDA Drug Safety Information 
Entecavir (Baraclude® ) and potential for the development of HIV (human immunodeficiency virus) resistance in HIV/HBV co-infected patients who are not also receiving highly active antiretroviral therapy (HAART)   8/16/2007  Dear Healthcare Professional Letter (Bristol-Myers Squibb) 
Rosiglitazone and Risk of Heart Failure  8/14/2007  FDA Information for Healthcare Professionals 
Pioglitazone and Risk of Heart Failure  8/14/2007  FDA Information for Healthcare Professionals 
Omeprazole (Prilosec®) and Esomeprazole (Nexium®) and Cardiovascular Events  8/9/2007  Early Communication about an Ongoing Safety Review 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products UPDATE  8/1/2007  Dear Healthcare Professional Letter (Roche) 
Omalizumab (Xolair®) and Anaphylactic Reactions  7/10/2007  National PBM Bulletin 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products  7/5/2007  FDA Alert 
Trimetrexate Glucuronate (Neutrexin®) and Drug Discontinuation  3/16/2007  Dear Healthcare Professional Letter 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products  6/1/2007  Dear Healthcare Professional Letter 
Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging (marketed as Magnevist, MultiHance, Omniscan, OptiMARK, ProHance) and Risk for Nephrogenic Systemic Fibrosis  5/23/2007  FDA Alert 
Rosiglitazone (Avandia®) and Cardiovascular Events  5/22/2007  Information for Healthcare Professionals 
Rosiglitazone (Avandia®) and Cardiovascular Events  5/21/2007  FDA Alert 
Rosiglitazone (Avandia®) and Cardiovascular Events  5/21/2007  FDA News 
Pergolide (Permax®) and Heart Valve Damage  5/14/2007  National PBM Bulletin
Antidepressant Medications and New Warnings About Suicidal Thinking, Behavior in Young Adults   5/2/2007  FDA Press Release 
Ceftriaxone (Rocephin®) and Incompatibility with Calcium Products UPDATE  5/1/2007  Prescribing Information (Roche) 
Zolpidem (Ambien®) High Dose Use and Dose-Related Adverse Events  5/1/2007  Review of Various Trials Using Zolpidem at Higher Doses 
Look-Alike Sound-Alike Confusion Potential with Humapen Memoir® and Humira® Pen  4/5/2007  Humira Pen and HumaPen; ISMP Newsletter 
Tegaserod and Discontinued Marketing for Safety Reasons  4/3/2007  National PBM Bulletin 
Methadone (Dolophine®) and Serious Side Effects  4/1/2007  Methadone Related Deaths; PBM Ez Minutes April-June 2007 
Pergolide (Permax®) and Heart Valve Damage  3/29/2007  FDA Public Health Advisory 
Lamivudine and Zidovudine (Combivir®) Tablets and Counterfeit Labeling  3/28/2007  Dear Pharmacy Professional Letter 
Linezolid (Zyvox®) and Increased Mortality  3/16/2007  FDA Alert 
Linezolid (Zyvox®) and Increased Mortality  3/16/2007  Healthcare Professional Sheet 
Telithromycin (Ketek®) and Safety Issues  3/1/2007  Dear Healthcare Professional Letter 
Omalizumab (Xolair®) and Anaphylactic Reactions  2/21/2007  FDA Alert 
Omalizumab (Xolair®) and Anaphylactic Reactions  2/21/2007  FDA News 
Omalizumab (Xolair®) and Anaphylactic Reactions  2/21/2007  Healthcare Professional Sheet 
Telithromycin (Ketek®) and Serious Liver Toxicity  2/12/2007  FDA News – Label and Indication Changes 
Telithromycin (Ketek®) and Serious Liver Toxicity  2/12/2007  Questions and Answers on Telithromycin 
Quinine and Unapproved Use for Leg Cramps Due to Serious Side Effects  2/8/2007  National PBM Bulletin 
IV Promethazine (Phenergan®) and Tissue Injury  2/1/2007  A Guidance on IV Promethazine Use and Safety Issues 
Erythropoiesis Stimulating Agents Safety Alert  1/9/2007  National PBM Bulletin 
Erythropoiesis Stimulating Agents Safety Alert  1/9/2007  Safety Concerns of Erythropoiesis Stimulating Agents 
Look-Alike Sound-Alike Confusion Potential with Humapen Memoir® and Humira® Pen  1/1/2007  Two Pens Different Uses; PBM Ez-Minutes January-March 2007 
Quinine and Unapproved Use for Leg Cramps Due to Serious Side Effects  1/1/2007  Quinine Not for Leg Cramps Anymore; PBM Ez-Minutes January-March 2007 
Rituximab (Rituxan®) and Progressive Multifocal Leukoencephalopathy  12/18/2006  FDA Alert 
Rituximab (Rituxan®) and Progressive Multifocal Leukoencephalopathy  12/18/2006  FDA Information for Healthcare Professionals 
Quinine and Unapproved Use for Leg Cramps Due to Serious Side Effects  12/11/2006  FDA News 
Quinine and Unapproved Use for Leg Cramps Due to Serious Side Effects  12/11/2006  FDA Questions and Answers on Unapproved Quinine Products 
Methadone (Dolophine®) and Serious Side Effects   11/30/2006  National PBM Bulletin 
Methadone (Dolophine®) and Serious Side Effects   11/30/2006  VAMedSAFE Bulletin 
Methadone (Dolophine®) and Serious Side Effects   11/27/2006  FDA Alert 
Methadone (Dolophine®) and Serious Side Effects   11/27/2006  Healthcare Provider Information 
Oseltamivir Phosphate (Tamiflu®) and Precaution for Neuropsychiatric Events   11/13/2006  Dear Healthcare Professional Letter 
Fluarix® and Twinrix® Look-Alike Confusion Potential   11/1/2006  National PBM Bulletin 
Bevacizumab  10/1/2006  National PBM Bulletin 
Look-Alike Sound-Alike Vaccine Mix-ups: Adacel (Tdap) and Daptacel (DTaP)   8/24/2006  ISMP Newsletter 
IV Promethazine (Phenergan®) and Tissue Injury   8/10/2006  ISMP Newsletter 
Telithromycin (Ketek®) and Serious Liver Toxicity  7/5/2006  Questions and Answers on Telithromycin 
Telithromycin (Ketek®) and Serious Liver Toxicity  6/29/2006  FDA News for New Product Labeling Regarding Safety Issues 
Benzocaine  2/28/2006  A Guidance on the Use of topical Anesthetics for Naso/Oropharyngeal and Laryngotracheal Procedures 
Benzocaine  2/10/2006  FDA Public Health Advisory 
Benzocaine  2/8/2006  NCPS Patient Safety Alert 
Telithromycin (Ketek®) and Serious Liver Toxicity  1/20/2006  FDA Public Health Advisory 
Telithromycin (Ketek®) and Serious Liver Toxicity  1/20/2006  Questions and Answers on Telithromycin 
Benzocaine  10/1/2005  VAMedSAFE Patient Safety Issues – Benzocaine (Hurricaine Spray); PBM Ez-Minutes October-December 2005 
Phosphodiesterase 5 Inhibitors and Loss of Vision  8/5/2005  National PBM Bulletin 
Clinical Guidance on Replacement Product Recommendations for Avandamet and Paxil CR in the VA   3/29/2005  National PBM Bulletin 
Vitamin E  1/13/2005  National PBM Bulletin 
Ethyl Chloride Safety Awareness  1/1/2005  Ethyl Chloride Ignites; PBM Ez-Minutes January-March 2005 
Fentanyl Transdermal Patch  12/22/2004  National PBM Bulletin 
HIV Agents New on Formulary  12/21/2004  National PBM Bulletin 
Vitamin E  12/1/2004  VAMedSAFE Bulletin 
Vitamin E  12/1/2004  Background: High Dose Vitamin E (> 400IU/Day) 
Statins  9/1/2004  Statin-Fibrate Report – Focus on Safety 
Rofecoxib  7/21/2004  National PBM Bulletin 
Statins  12/1/2001  Recommendations for the Use of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors (statins) in Veteran Patients Receiving Medications with the Potential for Drug-Drug Interactions 
Oxycontin – Diversion and Abuse  12/1/2001 

VA Office of Inspector General Pharmaceutical Bulletin 

 

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